Cyclodextrins used as excipients
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Cyclodextrins in eye drop formulations: enhanced topical delivery of corticosteroids to the eye.
Cyclodextrins are cylindrical oligosaccharides with a lipophilic central cavity and hydrophilic outer surface. They can form water-soluble complexes with lipophilic drugs, which 'hide' in the cavity. Cyclodextrins can be used to form aqueous eye drop solutions with lipophilic drugs, such as steroids and some carbonic anhydrase inhibitors. The cyclodextrins increase the water solubility of the d...
متن کاملThe Development of a New Complexation Technique of Hydrocortisone Acetate with 2-Hydroxypropyl-β-Cyclodextrin: Preparation and Characterization
The Hydrocortisone acetate (Figure 1) is a white crystalline powder; it melts at about 220°C with decomposition and is practically insoluble in water 1mg/100mL [2]. One method to overcome the poorly water solubility of HA is the use of cyclodextrins (CDs), which have been extensively studied [3]. CDs have been extensively used as complexing agents to improve the solubility of a variety of poorl...
متن کاملCytotoxicity of Different Excipients on RPMI 2650 Human Nasal Epithelial Cells.
The nasal route receives a great deal of attention as a non-invasive method for the systemic administration of drugs. For nasal delivery, specific formulations containing excipients are used. Because of the sensitive respiratory mucosa, not only the active ingredients, but also additives need to be tested in appropriate models for toxicity. The aim of the study was to measure the cytotoxicity o...
متن کاملPotential Impact of Cyclodextrin-Containing Formulations in Toxicity Evaluation of Novel Compounds in Early Drug Discovery
Cyclodextrins (CDs) are widely used as enabling excipients to improve in vivo drug delivery. The ability of CDs to form inclusion complexes with drugs and thereby improving solubility and stability of drugs is well established, and has been successfully used for several drugs on the market. Combined with well established preclinical and clinical safety profiles for selected CDs, they are of int...
متن کاملNano-Assemblies of Modified Cyclodextrins and Their Complexes with Guest Molecules: Incorporation in Nanostructured Membranes and Amphiphile Nanoarchitectonics Design
A variety of cyclodextrin-based molecular structures, with substitutions of either primary or secondary faces of the natural oligosaccharide macrocycles of α-, β-, or γ-cyclodextrins, have been designed towards innovative applications of self-assembled cyclodextrin nanomaterials. Amphiphilic cyclodextrins have been obtained by chemical or enzymatic modifications of their macrocycles using phosp...
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